Heterogeneity of Informant-Reported Functional Impairments in Older Adults

 
   Lead Investigator:    Rachel Mis
   Institution      :    Temple University
   E-Mail           :    rachel.mis@temple.edu
   Proposal ID      :    862


   Publications:


1  Divers R, Hackett K, Clark K, Mis R, Giovannetti T
   Heterogeneity of Subtle Functional Impairment Across MCI Subtypes
   2019   Abstract  International Neuropsychological Society Annual Meeting , 

   PRESENTED



2  Hackett K, Mis R, Divers R, Giovannetti T
   Sources of Bias in Informant-Rated Everyday Functioning in MCI
   2018   Abstract  2019 International Neuropsychological Meeting , 

   SUBMITTED



3  Hackett K, Mis R, Drabick DAG, Giovannetti
   Informant Reporting in Mild Cognitive Impairment: Sources of Bias and Inaccuracy on the Functional Activities Questionnaire
   Journal Article  J Int Neuropsychol Soc,26:503-514,2020,PMC7205566

   PUBLISHED



4  Mis R, Devlin K, Drabick D, Giovannetti T
   Heterogeneity of Informant-Reported Functional Performance in Mild Cognitive Impairment: A Latent Class Analysis of the Functional Activities Questionnaire
   2018   Abstract  International Neuropsychological Society Annual Meeting , 

   PRESENTED



5  Mis R, Devlin K, Drabick D, Giovannetti T
   Heterogeneity of Informant-Reported Functional Performance in Mild Cognitive Impairment: A Latent Class Analysis of the Functional Activities Questionnaire
   Journal Article  J Alzheimers Dis,4:1611-1624,2019,PMC in process

   PUBLISHED



6  Mis R, Drabick D, Giovannetti T
   Lontitudinal Trajectories of Cognitive Change in Healthy Older Adults
   2020   Abstract  International Neuropsychological Society Annual Meeting , 

   PRESENTED





   Proposal Description:
   Impairments in functional activities of daily life are increasingly recognized    as features of mild cognitive impairment, though the heterogeneity in patterns    of functional decline remains to be fully characterized. Prior studies suggest    that the particular types of functional activities impaired differ across types   of underlying cognitive deficits (e.g., amnestic single domain MCI compared to    non-amnestic single domain MCI). We propose to conduct a latent class analysis    (LCA) of responses to the Functional Activities Questionnaire (FAQ) data within   the National Alzheimer???s Coordinating Center (NACC) database from               participants with a diagnosis of cognitively-normal or MCI. Results will be       discussed in terms of the classes found by the LCA and their relation to          demographic variables and measures of cognitive functioning. We hypothesize       that the LCA will reveal four classes related to cognitively-healthy              individuals, amnestic single domain MCI, non-amnestic single domain MCI, and      amnestic and non-amnestic multiple domain MCI. A second aim of the proposed       study is to evaluate the strength of the association between cognition and        education compared to the association between cognition and functional            abilities. The results of the study have the potential to inform our              understanding of the cognitive processes underlying everyday action, prediction   of cognitive and functional decline, and interventions to preserve functional     independence.